Epilepsy is typically diagnosed through electroencephalography (EEG) and long-term video-EEG (vEEG) monitoring. The manual analysis of vEEG recordings is time-consuming, necessitating automated tools for seizure detection. Recent advancements in machine learning have shown promise in real-time seizure detection and prediction using EEG and video data. However, diversity of seizure symptoms, markup ambiguities, and limited availability of multimodal datasets hinder progress. This paper reviews the latest developments in automated video-EEG analysis and discusses the integration of multimodal data. We also propose a novel pipeline for treatment effect estimation from vEEG data using concept-based learning, offering a pathway for future research in this domain.

Epilepsy is a prevalent neurological disorder marked by sudden, brief episodes of excessive neuronal activity caused by abnormal electrical discharges, which may lead to some mental disorders. Most existing deep learning methods for epilepsy detection rely solely on unimodal EEG signals, neglecting the potential benefits of multimodal information. To address this, we propose a novel multimodal model, DistilCLIP-EEG, based on the CLIP framework, which integrates both EEG signals and text descriptions to capture comprehensive features of epileptic seizures. The model involves an EEG encoder based on the Conformer architecture as a text encoder, the proposed Learnable BERT (BERT-LP) as prompt learning within the encoders. Both operate in a shared latent space for effective cross-modal representation learning. To enhance efficiency and adaptability, we introduce a knowledge distillation method where the trained DistilCLIP-EEG serves as a teacher to guide a more compact student model to reduce training complexity and time. On the TUSZ, AUBMC, and CHB-MIT datasets, both the teacher and student models achieved accuracy rates exceeding 97%. Across all datasets, the F1-scores were consistently above 0.94, demonstrating the robustness and reliability of the proposed framework. Moreover, the student model's parameter count and model size are approximately 58.1% of those of the teacher model, significantly reducing model complexity and storage requirements while maintaining high performance. These results highlight the potential of our proposed model for EEG-based epilepsy detection and establish a solid foundation for deploying lightweight models in resource-constrained settings.

Automated epileptic seizure detection from electroencephalogram (EEG) remains challenging due to significant individual differences in EEG patterns across patients. While existing studies achieve high accuracy with patient-specific approaches, they face difficulties in generalizing to new patients. To address this, we propose a detection framework combining domain adversarial training with a convolutional neural network (CNN) and a bidirectional long short-term memory (BiLSTM). First, the CNN extracts local patient-invariant features through domain adversarial training, which optimizes seizure detection accuracy while minimizing patient-specific characteristics. Then, the BiLSTM captures temporal dependencies in the extracted features to model seizure evolution patterns. Evaluation using EEG recordings from 20 patients with focal epilepsy demonstrated superior performance over non-adversarial methods, achieving high detection accuracy across different patients. The integration of adversarial training with temporal modeling enables robust cross-patient seizure detection.

Epilepsy is a prevalent neurological disorder globally, impacting around 50 million people \cite{WHO_epilepsy_50million}. Epileptic seizures result from sudden abnormal electrical activity in the brain, which can be read as sudden and significant changes in the EEG signal of the brain. The signal can vary in severity and frequency, which results in loss of consciousness and muscle contractions for a short period of time \cite{epilepsyfoundation_myoclonic}. Individuals with epilepsy often face significant employment challenges due to safety concerns in certain work environments. Many jobs that involve working at heights, operating heavy machinery, or in other potentially hazardous settings may be restricted for people with seizure disorders. This certainly limits job options and economic opportunities for those living with epilepsy.

Electroencephalography (EEG) analysis extracts critical information from brain signals, which has provided fundamental support for various applications, including brain-disease diagnosis and brain-computer interface. However, the real-time processing of large-scale EEG signals at high energy efficiency has placed great challenges for electronic processors on edge computing devices. Here, we propose the EEG opto-processor based on diffractive photonic computing units (DPUs) to effectively process the extracranial and intracranial EEG signals and perform epileptic seizure detection. The signals of EEG channels within a second-time window are optically encoded as inputs to the constructed diffractive neural networks for classification, which monitors the brain state to determine whether it's the symptom of an epileptic seizure or not. We developed both the free-space and integrated DPUs as edge computing systems and demonstrated their applications for real-time epileptic seizure detection with the benchmark datasets, i.e., the CHB-MIT extracranial EEG dataset and Epilepsy-iEEG-Multicenter intracranial EEG dataset, at high computing performance. Along with the channel selection mechanism, both the numerical evaluations and experimental results validated the sufficient high classification accuracies of the proposed opto-processors for supervising the clinical diagnosis. Our work opens up a new research direction of utilizing photonic computing techniques for processing large-scale EEG signals in promoting its broader applications.

Abstract: In this paper, we propose a personalized seizure detection and classification framework that quickly adapts to a specific patient from limited seizure samples. We achieve this by combining two novel paradigms that have recently seen much success in a wide variety of real-world applications: graph neural networks (GNN), and meta-learning. We train a Meta-GNN based classifier that learns a global model from a set of training patients such that this global model can eventually be adapted to a new unseen patient using very limited samples. We apply our approach on the TUSZ-dataset, one of the largest and publicly available benchmark datasets for epilepsy. We show that our method outperforms the baselines by reaching 82.7% on accuracy and 82.08% on F1 score after only 20 iterations on new unseen patients.

Abstract: During the past two decades, epileptic seizure detection and prediction algorithms have evolved rapidly. However, despite significant performance improvements, their hardware implementation using conventional technologies, such as Complementary Metal-Oxide-Semiconductor (CMOS), in power and area-constrained settings remains a challenging task; especially when many recording channels are used. In this paper, we propose a novel low-latency parallel Convolutional Neural Network (CNN) architecture that has between 2–2,800x fewer network parameters compared to SOTA CNN architectures and achieves 5-fold cross validation accuracy of 99.84% for epileptic seizure detection, and 99.01% and 97.54% for epileptic seizure prediction, when evaluated using the University of Bonn Electroencephalogram (EEG), CHB-MIT and SWEC-ETHZ seizure datasets, respectively. We subsequently implement our network onto analog crossbar arrays comprising Resistive Random-Access Memory (RRAM) devices, and provide a comprehensive benchmark by simulating, laying out, and determining hardware requirements of the CNN component of our system. To the best of our knowledge, we are the first to parallelize the execution of convolution layer kernels on separate analog crossbars to enable 2 orders of magnitude reduction in latency compared to SOTA hybrid Memristive-CMOS DL accelerators.

Epilepsy is a neurological brain disorder which life threatening and gives rise to recurrent seizures that are unprovoked. It occurs due to the abnormal chemical changes in our brain. Over the course of many years, studies have been conducted to support automatic diagnosis of epileptic seizures for the ease of clinicians. For that, several studies entail the use of machine learning methods for the early prediction of epileptic seizures. Mainly, feature extraction methods have been used to extract the right features from the EEG data generated by the EEG machine and then various machine learning classifiers are used for the classification process. This study provides a systematic literature review of feature selection process as well as the classification performance. This study was limited to the finding of most used feature extraction methods and the classifiers used for accurate classification of normal to epileptic seizures. The existing literature was examined from well-known repositories such as MPDI, IEEEXplore, Wiley, Elsevier, ACM, Springerlink and others. Furthermore, a taxonomy was created that recapitulates the state-of-the-art used solutions for this problem. We also studied the nature of different benchmark and unbiased datasets and gave a rigorous analysis of the working of classifiers. Finally, we concluded the research by presenting the gaps, challenges and opportunities which can further help researchers in prediction of epileptic seizure

Epilepsy is a disorder of the brain denoted by frequent seizures. The symptoms of seizure include confusion, abnormal staring, and rapid, sudden, and uncontrollable hand movements. Epileptic seizure detection methods involve neurological exams, blood tests, neuropsychological tests, and neuroimaging modalities. Among these, neuroimaging modalities have received considerable attention from specialist physicians. One method to facilitate the accurate and fast diagnosis of epileptic seizures is to employ computer-aided diagnosis systems (CADS) based on deep learning (DL) and neuroimaging modalities. This paper has studied a comprehensive overview of DL methods employed for epileptic seizures detection and prediction using neuroimaging modalities. First, DL-based CADS for epileptic seizures detection and prediction using neuroimaging modalities are discussed. Also, descriptions of various datasets, preprocessing algorithms, and DL models which have been used for epileptic seizures detection and prediction have been included. Then, research on rehabilitation tools has been presented, which contains brain-computer interface (BCI), cloud computing, internet of things (IoT), hardware implementation of DL techniques on field-programmable gate array (FPGA), etc. In the discussion section, a comparison has been carried out between research on epileptic seizure detection and prediction. The challenges in epileptic seizures detection and prediction using neuroimaging modalities and DL models have been described. In addition, possible directions for future works in this field, specifically for solving challenges in datasets, DL, rehabilitation, and hardware models, have been proposed. The final section is dedicated to the conclusion which summarizes the significant findings of the paper.

Electroencephalogram (EEG) is one of the main diagnostic tests for epilepsy. The detection of epileptic activity is usually performed by a human expert and is based on finding specific patterns in the multi-channel electroencephalogram. This is a difficult and time-consuming task, therefore various attempts are made to automate it using both conventional and Deep Learning (DL) techniques. Unfortunately, authors do not often provide sufficiently detailed and complete information to be able to reproduce their results. Our work is intended to fill this gap. Using a carefully selected 79 neonatal EEG recordings we developed a complete framework for seizure detection using DL approch. We share a ready to use R and Python codes which allow: (a) read raw European Data Format files, (b) read data files containing the seizure annotations made by human experts, (c) extract train, validation and test data, (d) create an appropriate Convolutional Neural Network (CNN) model, (e) train the model, (f) check the quality of the neural classifier, (g) save all learning results.